Surgeon-Led Specialist Clinic

Led by plastic surgeon Dr. Ayad Harb, we pride ourselves on the standard of care, quality and safety of our treatments.

Central Clinic Locations

SRGN has three state of the art clinic locations in Central London, Bicester & Ascot.

Care Quality Commission

We're regulated by the independent regulator of health and social care in England.

GMC Registered Surgeons

All of our surgeons are registered with the General Medical Council.




Medically Reviewed April 2023, by Dr. Ayad Harb, one of the world's leading plastic surgeons

What is Pigmentation? 

Pigmentation refers to the coloring of the skin, hair, mucous membranes, and retina of the eyes. This coloration is mainly determined by melanin, a pigment produced by specialized cells called melanocytes within the epidermis. Melanin is responsible for determining the color of various parts of the body, playing a significant role in our appearance. The way pigmentation manifests in individuals is a complex biological process influenced by various factors, including genetics, exposure to sunlight, hormones, and other physiological mechanisms.

Skin pigmentation, although generally consistent throughout an individual's life, can become disrupted, leading to pigmentation disorders. These disorders can cause either an increase or a decrease in melanin production, resulting in noticeable changes in skin color. Pigmentation changes can not only affect the aesthetics of the skin but can also be indicative of underlying health issues.

One of the most common causes of altered pigmentation is exposure to ultraviolet (UV) rays from the sun. The UV rays can stimulate melanin production, leading to sunspots, tanning, or an uneven skin tone. Many individuals seek tanned skin as a sign of health and vitality, but excessive exposure to UV rays can cause long-term skin damage and lead to various pigmentation disorders.

Hormonal changes are another significant factor in pigmentation. Conditions like pregnancy can result in a specific type of pigmentation known as melasma. This hormone-related pigmentation often appears as dark, irregular patches on the face or other body parts exposed to the sun. While melasma might fade after pregnancy, it can sometimes persist, causing distress to the affected individuals.

Injuries or inflammation of the skin can also alter pigmentation. A phenomenon known as post-inflammatory hyperpigmentation can occur after an injury or inflammatory skin condition such as acne or eczema. This condition causes the affected area to darken compared to the surrounding skin, often leading to noticeable contrast.

Pigmentation disorders are classified into various types, depending on whether there is an increase or decrease in melanin production or an abnormal distribution of melanin. Hyperpigmentation refers to the condition where there is an increase in melanin, causing dark spots or patches on the skin. Hypopigmentation, on the other hand, is characterized by a decrease in melanin production, resulting in lighter patches of skin. Vitiligo is a specific type of pigmentation disorder, an autoimmune condition that leads to loss of melanin in patches, creating a stark contrast between affected and unaffected areas.

Treating pigmentation disorders requires a careful understanding of the underlying cause and may necessitate a combination of treatments. Topical medications containing specific ingredients like hydroquinone are often used to lighten the pigmented areas. These medications work by inhibiting the enzymes responsible for melanin production, thus reducing the appearance of dark spots.

Laser therapy is another advanced option for treating pigmentation. By targeting specific pigmentation with light energy, the laser can break down the melanin clusters, allowing the body to absorb and remove them. This method has shown effectiveness in treating various types of pigmentation but requires careful handling by trained medical professionals to avoid potential side effects.

Chemical peels, utilizing carefully selected acids, provide another approach to managing pigmentation. By exfoliating the skin's surface and removing pigmented cells, chemical peels stimulate new skin growth, often leading to a more even and youthful appearance. Chemical peels vary in intensity and composition and should be administered by a qualified skincare professional to ensure safety and effectiveness.

One specialized treatment gaining recognition for treating pigmentation disorders is the Cosmelan De-pigmentation Peel. This treatment combines various ingredients to inhibit melanin production while removing superficial pigmentation. It is particularly known for its efficacy in treating melasma and other hyperpigmentation disorders, offering a targeted solution for those struggling with these challenging conditions.

Pigmentation is a multifaceted aspect of human biology with both aesthetic and medical significance. Changes in pigmentation may reflect underlying health issues, genetic predispositions, or environmental exposures. Understanding the various factors influencing pigmentation and the available treatments requires a comprehensive approach, often necessitating consultation with dermatologists or medical skincare professionals. With the advancement of medical science, there are now more options than ever to address pigmentation disorders, offering hope and solutions to those seeking to restore their skin's natural beauty and health.

What Causes Pigmentation? 

Genetic Factors and Inherited Conditions

Pigmentation is often determined by genetics, dictating the amount of melanin a person's skin produces and how it's distributed. Everyone inherits genes from both parents that carry information about skin, hair, and eye color. Genetic mutations may lead to certain pigmentation disorders like albinism, where there is little or no melanin production, resulting in very pale skin, white or light-colored hair, and light-colored eyes.

Familial patterns of pigmentation disorders can also occur, where specific pigmentation characteristics are passed down through generations. Genetic counseling and testing may be utilized to understand these patterns and provide insights into potential risks for family members. Overall, the genetic makeup of an individual plays a substantial role in determining skin pigmentation and can lead to various inherited pigmentation conditions.

Sun Exposure and Environmental Factors

The sun's ultraviolet (UV) rays are a significant factor in causing pigmentation changes. UV rays stimulate melanocytes to produce more melanin, leading to tanning, freckles, sunspots, or uneven skin tone. While mild tanning might be considered aesthetically pleasing, prolonged and excessive sun exposure can cause long-term skin damage, leading to various pigmentation disorders. Sunscreen and protective clothing are often advised to mitigate these risks.

Environmental pollutants and toxins can also contribute to pigmentation changes. Exposure to heavy metals or chemicals might cause localized or generalized pigmentation disorders, emphasizing the importance of understanding the interplay between environmental factors and skin health.

Hormonal Changes and Medical Conditions

Hormones play an essential role in influencing pigmentation. Conditions like pregnancy, menopause, or thyroid disorders can lead to hormonal imbalances, resulting in pigmentation changes. Melasma, often called the "mask of pregnancy," is an example where hormonal fluctuations cause dark, irregular patches on the skin.

Certain medications and medical treatments, such as chemotherapy, may also lead to pigmentation changes. Monitoring and understanding these changes is vital in both diagnosing underlying health conditions and managing patient well-being.

Skin Injuries and Inflammation

Injuries, burns, or inflammation from conditions like acne or eczema can lead to post-inflammatory hyperpigmentation. This phenomenon occurs when the skin's healing process triggers excess melanin production, causing the affected area to darken. Although often temporary, this can cause distressing and noticeable changes in appearance. Treatment may require time and various therapeutic interventions.

Pigmentation is influenced by a multitude of factors, ranging from genetics to environmental exposures to underlying health conditions. Understanding these influences requires a holistic approach, often involving collaboration between dermatologists, genetic counselors, and other healthcare providers. The multifaceted nature of pigmentation illustrates the complexity of human skin and the careful balance required to maintain its health and appearance.


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Types of Pigmentation


Hyperpigmentation is a common type of pigmentation disorder characterized by the darkening of certain areas of the skin. This darkening occurs when there is an excess production of melanin, the pigment responsible for skin color. Various factors can contribute to hyperpigmentation, including sun exposure, hormonal changes, aging, and specific medical conditions.

Sunspots, liver spots, and melasma are all examples of hyperpigmentation. Sunspots are typically a result of chronic sun exposure, while melasma is often associated with hormonal changes, such as those during pregnancy or while taking birth control pills. Hyperpigmentation can also occur as a reaction to skin injuries or inflammation, such as acne scars.

Treatment for hyperpigmentation varies based on the underlying cause and may include topical creams, laser therapy, or chemical peels. These therapies often aim to reduce melanin production or remove the surface layer of the skin to reveal a more evenly pigmented layer beneath. Dermatological consultation is often recommended to determine the most appropriate treatment approach for hyperpigmentation.


Hypopigmentation refers to a reduction in skin color due to a decrease in melanin production. Unlike hyperpigmentation, where the skin becomes darker, hypopigmentation results in lighter patches of skin. This can occur for various reasons, including genetic disorders like albinism, skin infections, burns, or other types of trauma to the skin.

One common example of hypopigmentation is vitiligo, an autoimmune condition where the body's immune system attacks melanocytes, leading to the loss of pigment in patches across the skin. Vitiligo can affect any part of the body, and its progression can be unpredictable.

Hypopigmentation may require more complex treatment approaches, particularly when it's linked to underlying medical conditions. Therapies such as light or laser treatments, camouflage makeup, or skin grafting may be employed, often requiring specialized care by dermatologists or other medical professionals.


Melasma is a specific type of hyperpigmentation often referred to as the "mask of pregnancy." It's characterized by brown or grayish patches of pigmentation, usually on the face, particularly the cheeks, forehead, nose, and upper lip. While it's common during pregnancy due to hormonal changes, melasma can also affect women taking birth control or undergoing hormone replacement therapy.

The precise cause of melasma is not entirely understood, but it's believed to involve a combination of genetic predisposition, hormonal changes, and UV radiation. Treatment often involves a multifaceted approach, including sun protection, topical bleaching agents, laser therapy, or chemical peels. Melasma can be a persistent and challenging condition to treat, requiring ongoing care and management.


Vitiligo is an autoimmune disorder characterized by hypopigmentation, where the body's immune system mistakenly targets and destroys melanocytes, the cells responsible for producing melanin. This leads to a loss of pigment in patches, creating a stark contrast between affected and unaffected areas. Vitiligo can occur at any age and may affect any part of the body.

The exact cause of vitiligo remains unknown, but it may be linked to genetic factors, oxidative stress, or neural causes. Treatment for vitiligo aims to restore color balance and may include therapies like corticosteroid creams, phototherapy, laser treatment, or even surgical methods like skin grafting.

These types of pigmentation, from hyperpigmentation to specific conditions like melasma and vitiligo, illustrate the complexity of skin pigmentation and the intricate interplay of factors that govern our skin color. Each condition has its characteristics, underlying causes, and treatment approaches, emphasizing the importance of professional diagnosis and individualized care.

Treatments of Pigmentation

Topical Medications

Topical medications are often the first line of treatment for various pigmentation disorders, especially hyperpigmentation. These are creams, lotions, or gels containing active ingredients that inhibit the enzymes responsible for melanin production.

One common ingredient in these products is hydroquinone, which works by reducing the production of melanin. Other components like kojic acid, azelaic acid, and vitamin C are also utilized for their skin-lightening properties. Prescription-strength formulations usually provide more noticeable results and are often guided by a dermatologist or healthcare provider.

The application of topical medications requires careful adherence to instructions, as overuse or misuse can lead to skin irritation or worsening of the pigmentation. Sun protection is usually advised during treatment, as UV exposure can counteract the effects of the medication.

Topical medications offer a non-invasive approach to managing pigmentation, suitable for mild to moderate cases. The success of treatment can vary based on the underlying cause of the pigmentation, individual skin type, and compliance with the treatment regimen.

Laser Therapy

Laser therapy has become a widely accepted treatment for various pigmentation disorders. Utilizing specific wavelengths of light, laser therapy targets melanin within the skin, breaking it down and allowing the body to absorb and remove it.

Laser therapy is often performed in multiple sessions, with the number and frequency of treatments tailored to the type and extent of pigmentation. The treatment requires careful calibration and handling by trained medical professionals, as improper use can lead to scarring or further pigmentation changes.

Different types of lasers are used to treat various pigmentation conditions, and the choice of laser depends on factors like skin type, the depth of pigmentation, and the desired outcomes. Cooling mechanisms are often employed during the procedure to minimize discomfort.

Post-treatment care may include moisturizing and sun protection to facilitate healing and prevent potential side effects. Laser therapy has proven effective for many individuals but requires a thorough consultation with a dermatologist or skin specialist to determine suitability and expected outcomes.

Chemical Peels

Chemical peels are another method used to treat pigmentation disorders. By applying a solution containing specific acids to the skin, chemical peels exfoliate the surface layer, removing pigmented cells and stimulating new skin growth.

Chemical peels vary in intensity and composition, ranging from mild superficial peels to more aggressive deep peels. The choice of peel depends on the type of pigmentation, the patient's skin type, and the desired results. Superficial peels may be used for mild pigmentation, while medium or deep peels may be chosen for more severe cases.

A skilled skincare professional must administer chemical peels, as improper application can lead to burns, scars, or uneven skin tone. Post-peel care usually involves moisturizing, sun protection, and avoiding certain skincare products that may irritate the newly exposed skin layer.

Chemical peels offer an option for those seeking to reduce pigmentation and improve overall skin texture and appearance. However, they require careful consideration and professional guidance to achieve optimal results.

Cosmelan De-pigmentation Peel

The Cosmelan De-pigmentation Peel is a specialized treatment known for treating melasma and other hyperpigmentation disorders. It combines various ingredients, including azelaic acid, kojic acid, and arbutin, to inhibit melanin production and remove superficial pigmentation.

The treatment typically begins with an in-office application of the peel, followed by an at-home maintenance regimen. The combination of ingredients not only targets pigmentation but also provides anti-aging benefits, improving overall skin texture and appearance.

Cosmelan is favored for its efficacy in treating challenging pigmentation conditions, offering a targeted solution that balances skin tone. It is suitable for various skin types and pigmentation levels, but a thorough consultation with a trained skincare professional is vital to assess suitability, guide treatment, and monitor progress.

The landscape of pigmentation treatments is diverse, with options ranging from topical medications to advanced laser therapy or specialized treatments like the Cosmelan De-pigmentation Peel. Understanding the underlying causes of pigmentation, individual skin characteristics, and treatment goals is essential in selecting the most appropriate approach. 

Professional guidance and individualized care are key to achieving successful outcomes in managing pigmentation disorders.

About Our Clinic

Located in the heart of Ascot, Bicester, and London, the SRGN Clinic exemplifies afusion of cutting-edge science, unparalleled skill, and an unwavering commitment to patient care. The clinic stands as a beacon of excellence in thefield of aesthetic and plastic surgery.

Leading the team at SRGN is Dr. Ayad Harb, a renowned plastic surgeon and aesthetic trainer. His expertise, honed by years of experience and a genuine passion for improving lives, defines the very core of the clinic's ethos. Dr. Harb's innovative techniques, combined with an artistic eye for detail, enable him to deliver consistently exceptional results that are tailored to each patient's individual needs and desires.

At SRGN, we believe in the transformative power of aesthetic and plastic surgery. Our treatments, ranging from non-invasive procedures to complex surgical interventions, are designed to enhance and accentuate your natural beauty. We strive to provide a safe, comfortable, and confidential environment where you can discuss your aesthetic goals openly, and together we create a treatment plan that brings these goals to life.

Every member of the SRGN team shares a deep commitment to patient care. We prioritise your comfort, safety, and satisfaction from the moment you step into our clinic. Each of our facilities mirrors the luxury and tranquility of their surroundings, offering a serene space where you can embark on your journey to self-improvement.

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